 | Sabaku no Gaara | Naruto | 2 |
 | Sabaku no Gaara | | 2 |
| Sabrina 'Bree' Osbourne | TransAmerica | 1 |
| Sagara Sosuke | Full Metal Panic | 1 |
| Saginomiya Masaru | Mahou Shounen Majorian | 1 |
| Sakuraba Anju | Gacha Gacha | 1 |
| Sakuragi Azuma | Shounen x Cinderella | 1 |
| Sakurazaka Kaoru | Yin-Yang! X-Change Alternative | 1 |
| Samurai Jack | Samurai Jack | 1 |
| Sanjay Saxena | | 1 |
| Sanji | One Piece | 1 |
| Saotome Akama | Couch Trips | 1 |
| Saotome Genma | Ranma ½ | 1 |
| Saotome Hayaima | Couch Trips | 1 |
| Saotome Ranma | Ranma ½ | 7 |
| Sarah Brown | El Goonish Shive | 1 |
| Satomi Azusa | Idol A | 1 |
| Satou Kohta | My Balls | 1 |
| Scruffy | Futurama | 1 |
| Sendou Yukari | Rosario+Vampire | 1 |
| Senkawa Tsutomu | Birdy the Mighty | 1 |
| Senou Natsuru | Kämpfer | 2 |
 | Several Others | Rebellion | 1 |
| Severus Snape | Harry Potter | 2 |
| Shampoo | Ranma ½ | 1 |
| Shima Misaki | Futaba-kun Change | 1 |
| Shimeru Futaba | Futaba-kun Change | 2 |
| Shimeru Futana | Futaba-kun Change | 1 |
| Shimeru Kurin | Futaba-kun Change | 1 |
| Shining Armor | My Little Pony: Friendship is Magic | 1 |
| Shiowatari Nagisa | Urusei Yatsura | 2 |
| Shiraishi Akira | Ai wo Utau Yori Ore ni Oborero | 1 |
| Shirakawa 'White Dragon' Tatsuto | White Dragon | 1 |
| Shirayuki Rella | Cinderella Boy | 1 |
| Shōta Yanami | Blue Drop ~Angels We~ | 1 |
| Sirius Black | Harry Potter | 3 |
| Skuld | Oh! My Goddess | 1 |
| Soga Genzo | Tenshi na Konamaiki | 2 |
| Sohma Akito | Fruits Basket | 1 |
| Sohma Momiji | Fruits Basket | 2 |
| Song Liling | M. Butterfly | 1 |
| Soryuu Asuka Langley | Neon Genesis Evangelion | 2 |
| Steve Brooks | Switch | 1 |
| Stunt | Dominic Deegan: Oracle for Hire | 1 |
| Sudou Mitsuru | CUTE x GUY | 1 |
| Sugimoto Haruki | Kedamono Damono | 1 |
| Sugimoto Megumi | Kedamono Damono | 1 |
| Sugimoto Ryo | Kedamono Damono | 1 |
| Summoner | Nerdcore | 1 |
| Suoh Tamaki | Ouran High School Host Club | 1 |
| Suzuhara Tōji | Neon Genesis Evangelion | 1 |
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